Belimumab treatment in rhupus: A case report with severe skin involvement.

Patients with rhupus characteristically exhibit symmetric polyarthritis and clinical manifestations suggestive of systemic lupus erythematosus (malar rash, photosensitivity, hematological manifestations, serositis, and/or skin involvement) and positive anti-dsDNA. Treatment is unclear and it can include disease-modifying rheumatic drugs like hydroxyl chloroquine, or methotrexate or, in refractory cases, rituximab or abatacept. We report a case of 31-year-old female who present with rhupus with skin acute lesions treated with belimumab. This is the first case of rhupus treated with this drug described in the literature.

Dermatitis alérgica de contacto a parafenilendiamina por tatuajes con henna en población pediátrica / Para-phenylenediamine allergic contact dermatitis due to henna tattoos in a child and adolescent population

INTRODUCCIÓN: Los tatuajes con henna son una práctica común en la población adolescente. En la mayoría de las ocasiones, la henna se mezcla con parafenilendiamina (PPDA) para mejorar las características del tatuaje. La PPDA es un potente alérgeno que causa con frecuencia dermatitis alérgica de contacto. MATERIAL Y MÉTODO: Se recogió a 726 niños parcheados en la Unidad de Alergia del Hospital General Universitario de Valencia entre 1980 y 2015, identificándose los casos y revisando los resultados de las pruebas, así como datos clínicos y epidemiológicos. RESULTADOS: Trescientos sesenta y un niños (49,7%) demostraron sensibilización a al menos un alérgeno y 34 fueron alérgicos a la PPDA (4,68%). La edad media de los pacientes alérgicos a PPDA fue de 12,4 años. El 44,2% de los niños alérgicos eran varones. Dos pacientes (5,9%) presentaron antecedentes personales de atopia. El 73,5% de reacciones positivas a PPDA se consideraron de relevancia presente. El origen de la sensibilización fue la realización de un tatuaje con henna en el 50% de los pacientes. CONCLUSIÓN: La sensibilización a PPDA es relativamente frecuente en la población pediátrica. El origen más frecuente es la realización de tatuajes con henna adulterada. Los adolescentes son la población con mayor riesgo de presentar este tipo de reacciones. Se debe desaconsejar activamente la práctica de tatuajes con henna negra en la población pediátrica

INTRODUCTION: Henna tattoos are a very common practice in the adolescent population. Henna is very often admixed with para-phenylenediamine (PPDA) to improve the appearance of the tattoo. PPDA is a potent allergen, and is a frequent cause of allergic contact dermatitis (ACD). Material and method. A study was conducted on the results of 726 consecutive children who had been patch tested in the University General Hospital Consortium of Valencia between 1980 and 2015. RESULTS: Almost half (49.7%; (361 cases) of the children had one or more positive patch test findings, with 4.7% (34) being allergic to PPDA. Mean age of patients allergic to PPDA was 12.4 years, and 44.2% were male. There were 2 cases (5.9%) of atopic dermatitis. Of the positive reactions, 73.5% were considered to be current clinically relevant. The sensitisation origin was a Henna tattoo in 50% of cases. CONCLUSION: PPDA sensitisation is relatively common in the child and adolescent population. The most frequent origin is the performing of Henna tattoos adulterated with PPDA. Adolescents are at the higher risk of developing ACD due to Henna tattoos. Henna tattooing should be strongly discouraged in children

[Para-phenylenediamine allergic contact dermatitis due to henna tattoos in a child and adolescent population]. / Dermatitis alérgica de contacto a parafenilendiamina por tatuajes con henna en población pediátrica.

INTRODUCTION: Henna tattoos are a very common practice in the adolescent population. Henna is very often admixed with para-phenylenediamine (PPDA) to improve the appearance of the tattoo. PPDA is a potent allergen, and is a frequent cause of allergic contact dermatitis (ACD). MATERIAL AND METHOD: A study was conducted on the results of 726 consecutive children who had been patch tested in the University General Hospital Consortium of Valencia between 1980 and 2015. RESULTS: Almost half (49.7%; (361 cases) of the children had one or more positive patch test findings, with 4.7% (34) being allergic to PPDA. Mean age of patients allergic to PPDA was 12.4 years, and 44.2% were male. There were 2 cases (5.9%) of atopic dermatitis. Of the positive reactions, 73.5% were considered to be current clinically relevant. The sensitisation origin was a Henna tattoo in 50% of cases. CONCLUSION: PPDA sensitisation is relatively common in the child and adolescent population. The most frequent origin is the performing of Henna tattoos adulterated with PPDA. Adolescents are at the higher risk of developing ACD due to Henna tattoos. Henna tattooing should be strongly discouraged in children.

Vulvar Epidermal Inclusion Cyst as a Long-term Complication of Female Genital Mutilation.

We present a case report of a patient with epidermal inclusion cyst as a late complication of female genital mutilation (FGM). We describe the management of the patient, and a review of the literature. We report the clinical and pathological findings in a 37-year-old female patient from Nigeria, with a clitoral mass of 1 year duration. She declared to have an FGM since she was 5 years. The lesion was excised successfully with good cosmetic results. Histological examination revealed epidermal cyst with the presence of granular layer. An epidermal inclusion cyst can develop as a long-term consequence of FGM.

Síndrome de lupus neonatal inducido por anticuerpos antirribonucleoproteína / Neonatal lupus syndrome induced by anti-ribonucleoprotein antibodies

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Superficial angiomyxoma of the nipple: a case report of an infrequent cutaneous tumour.

Superficial angiomyxoma is a distinctive cutaneous soft tissue neoplasm that is clinically variable, infrequent, and benign. However, this tumor has a high propensity for local recurrence. There is a known association of angiomyxomas with Carney complex. We report a case of superficial angiomyxoma in a 28-year-old woman who presented with an erythematous, mul-tilobulated nodule on the nipple. This tumor has a predilection for the trunk, head and neck, extremities, and genitalia. The present case, hence, is unusual, because the lesion developed on the nipple. The appearance of a solitary cutaneous angiomyx-oma warrants an examination to rule out the presence of Carney complex. After clinical examination, echocardiogram and en-docrine analyses, Carney complex was ruled out in our patient.